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Thus, BPC 157, along with Nab2 , could serve as a controlling feedback mechanism and guarantee transient and controlled Egr1 activity (Tkalcevic et al., 2007) (consequently, Egr1 decreases later in the 24 hr period in the inferior caval vein while remaining increased in ovarian veins (Vukojevic et al., 2018), similar to its presentation in the hippocampus of ischemia/reperfusion rats)

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Mezaki T, Matsubara T

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Under the stimulation of FSH, the granulosa cells in the ovary secrete estradiol (E2) and inhibin, and the negative feedback regulates the secretion of the hypothalamus and pituitary gland so that the level of FSH gradually decreases