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Importantly, perfusion disorders are not exclusive to ALS but have also been observed in other neurodegenerative conditions such as AD and HD (Lambrechts et al

Where daily tissue repair (preclinical) starts

Pathological studies in degenerating neurons have demonstrated that S-nitrosylation of Drp1 specifically mediates aberrant mitochondrial recruitment, thereby triggering cascade activation of PINK1/PARKIN pathway-mediated mitophagy (Li et al., 2019)

For example, either oxidative stress or changes in intracellular Ca 2+ levels enhance the translocation of S100A2 from the nucleus to the cytoplasm