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The adverse effects of receptor-blocking bispecific antibodies are similar to their monospecific antibody counterparts such as skin rashes induced by amivantamab (also seen with EGFR-targeting antibodies cetuximab and panitumumab) and heart failure induced by zanidatamab (also seen with the HER2-targeting antibody trastuzumab) (Table 2)

Collagen also supports the skin barrier, reducing moisture loss and making skin more resilient to environmental aggressors

GHK-Cu peptide in skin and extracellular matrix research Due to its signaling profile, GHK-Cu peptide is commonly included in experimental models focused on skin biology and extracellular matrix regulation

These findings are associated with fibrosis of the pancreas

This has been confirmed by the increase in markers of OS such as carbonyls, malondialdehydes and 4-hydroxynonenal [40,41]
