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Similar content being viewed by others Introduction Reduced glutathione (GSH) provides the cellular first line of defense against oxidative stress-induced injury, which can be maintained by NADPH generated mainly via the pentose phosphate pathway and its rate-limiting enzyme, glucose-6-phosphate dehydrogenase (G6PD

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Xenograft model The animal experiments conducted in this study were ethically approved by the Institutional Animal Care and Use Committee of Zhejiang University (approval number: 20221576)

Furthermore, heterogeneity in diagnostic criteria across studies makes it challenging to compare outcomes consistently

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