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Under physiological conditions, Nrf2 primarily binds to its inhibitor, Keap1, and remains in an inactive state in the cytoplasm

[Abstract]2025 Dec:222:108027

[DOI] [PubMed] [Google Scholar] 75.Abraham N.G., Asija A., Drummond G., Peterson S

Once inside the cell, intracellular esterases convert calcein AM into calcein, a hydrophilic compound that fluoresces strongly and remains in the cytoplasm
[22] For example, even a very low dose of DMSO has a powerful protective effect against paracetamol (acetaminophen)-induced liver injury in mice

PINK1 stabilized by mitochondrial depolarization recruits parkin to damaged mitochondria and activates latent parkin for mitophagy
