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CENPT is found to be critical for regulating the glutathione (GSH) metabolism pathway because it interacts with -glutamyl-cysteine ligase catalytic subunit (GCLC), consequently reducing reactive oxygen species levels and inhibiting ferroptosis

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Gamete Res 24:185196

doi: 10.1016/s0891-5849(97)00009-9

Consequently, this reaction could lead to a decline in NAD + levels and an elevation in Hcy levels