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Sweeten TL, Posey DJ, Shankar S, McDougle CJ

Spatial biology and contact-site mapping ROS biology is orchestrated at organelle contact sites (MAMs, peroxisomemitochondria, mitochondrialysosome) and membrane microdomains, yet we lack tools to image, perturb and quantify multi-reactive chemistry there at cellular resolution in vivo

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Under fasting conditions, MTXs Tmax was attained in 0.752 h, and its Cmax ranged from 0.3 to 1.6 mol/L

Next, we detected the GPX4 and FTH1 levels in colorectal cancer patients undergoing neoadjuvant chemoradiotherapy by immunohistochemistry, and found both protein levels were up-regulated, compared with the patients without neoadjuvant chemoradiotherapy ( Figure 6A )