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423 Therefore, to overcome the acquired resistance through the usage of single inhibitory agent targeting one specific pathway may be difficult to obtain an extensive benefit with broad coverage

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[DOI] [PubMed] [Google Scholar] 126.Agricola R, Dalla Verde G, Urani R, Di Palma C, Giorgetti V

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The available observational studies reported even higher short-term efficacy rates

Notably, Arg1 expression in MDSCs contributes to arginine depletion in the microenvironment, further inhibiting T-cell antitumor function and reducing their survival