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GLP-1-based compounds work primarily through appetite suppression, and the weight loss they produce includes significant lean mass loss (approximately 40% of total weight lost is lean tissue based on STEP trial data)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Gonzalez-Muniesa P, Martinez-Gonzalez MA, Hu FB, Despres JP, Matsuzawa Y, Loos RJF, Moreno LA, Bray GA, Martinez JA

10.2337/db18-0780 15 BruckbauerA.BanerjeeJ.CaoQ.CuiX.JingJ.ZhaL.et al (2017)