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It appears that old age per se is not a risk factor for APAP toxicity, however, co-morbidities with impaired liver function, low body weight, polypharmacy, etc

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et al (2013) PLOS Genetics

The region of interest (ROI) was selected starting from 0.45 mm below the distal growth plate and extended for 0.45 mm proximally to measure the bone parameters, including trabecular bone volume fraction (Tb