melanotan 2 depression II (“Tan Jabs”): Why They're Not Worth The Risk Synaptic changes induced by melanocortin
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doi: 10.1016/j.pmr.2021.05.009

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A recent meta-analysis study reviewed twelve randomized controlled trials (RCTs) (n = 791) and found that ALC supplementation significantly reduced depressive symptoms in MDD as monotherapy and augmentation compared to placebo, with effect sizes comparable to standard antidepressants and a superior safety profile

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