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It has been proven effective with low toxicity in improving depressive-like behavior by reducing brain iron levels and tau protein levels (Rao et al., 2020

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187 Wy-14643 and gemfibrozil enhance autophagy in microglia and glioma, facilitating A clearance and cognitive improvement in AD models
Headline points: Both compounds independently produce dose-related nausea, vomiting, constipation, and decreased appetite
