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Description
The expression of the -glutamylcysteine synthetase gene of Escherichia coli B in Saccharomyces cerevisiae

Preclinical studies suggest that hypericin and its derivative hyperforin can mitigate imiquimod (IMQ)-induced psoriasis-like inflammation in murine models by downregulating IL-17A-producing T cells and associated cytokines.74 Specifically, hyperforin modulates MAPK/STAT3 signaling pathways, resulting in reduced epidermal thickening and lower pathological scores associated with skin lesions while inhibiting CD3+ T cell infiltration

Other studies have described reduced tumor growth and angiogenesis-related markers in experimental systems, potentially through modulation of Akt- and NF-B-associated signaling responses [82]

Strengthening the skin barrier and reducing moisture loss

NDDS offer a solution but introduce their own challenges: long-term biocompatibility, scalable manufacturing, cost-effectiveness, and comprehensive toxicology profiles are often inadequately addressed in proof-of-concept studies

doi: 10.1016/s1097-2765(00)80332-9, 60
