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That potency is exactly why the dose is not started high: the entire point of a titration protocol is to introduce the compound at a low, well-tolerated level and raise it in slow, roughly four-week steps so the gastrointestinal system can adapt

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The steroidreceptor complex moves into the cell nucleus and alters gene transcription

The Journal of Clinical Endocrinology & Metabolism , 85 (8), 26642669

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