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Previous researches demonstrated that the increase of inflammation in the brain with chronic sleep deprivation could boost the risk of neurodegenerative disease onset [121, 122]

[DOI] [PMC free article] [PubMed] [Google Scholar] Xue H.-M

Lipoic acid is a cofactor for the mitochondrial enzymes pyruvate dehydrogenase (PDH) and -ketoglutarate dehydrogenase (KGDH), which produce acetyl-CoA and succinyl-CoA, respectively [115]

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As per the general manifestation, since its minor items were closer to constitutional symptoms, such as myalgia, arthralgia/arthritis, fever, and weight loss, rather than those limited to a specific organ ( In the present study, serum GPX-3 concentration at diagnosis could not predict poor outcomes during follow-up in patients with AAV