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Sleep deprivation studies have provided first-hand information about the metabolic changes including the oxidative stress that occurs in the brain as well as peripheral organs as a result of insufficient or total lack of sleep (Vaccaro et al., 2020

doi: 10.1016/j.str.2012.03.021

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Advanced Dosing Strategies Experienced researchers may implement more sophisticated dosing strategies after establishing baseline responses: Pulse Dosing Alternating between higher and lower doses throughout the week may help maintain receptor sensitivity