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doi: 10.1016/j.chom.2009.09.005 68 WangRZhuYRenCYangSTianSChenHet al

Liver Expression of a MiniATP7B Gene Results in Long-Term Restoration of Copper Homeostasis in a Wilson Disease Model in Mice

Generally, these xenobiotic compounds are lipophilic, whereby they are likely to bind to lipid membranes and accumulate in adipose tissue as well as to be transported by lipoproteins in the blood and reach different compartments/organs

Further studies have shown that the combination of cisplatin and the ferroptosis inducer erastin enhances the antitumor effect of drugs, indicating that ferroptosis has great potential in antitumor therapy, thus opening a new manner for the in-depth application of classical drugs 44

And retatrutide, a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, achieved up to 24% weight loss in early trials

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