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Structural changes such as cardiomyopathy, cardiac hypertrophy, interstitial cardiac fibrosis, endothelial dysfunction, and contractile protein failure can result from elevated oxidative stress in cardiac tissue (Emran et al

Stewart et al., 2018)

A scoping review of 92 studies found that family caregivers frequently report psychological strain, social isolation, and practical stressors while supporting a loved one

Greater microbial translocation and vulnerability to metabolic disease in healthy aged female monkeys

In contrast, within the evolutionary framework, chronic pain beyond normal healing and chronic or relapsing depression are viewed as maladaptive processes which are maintained by neuropathological abnormalities