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This observation means that xCT blockage induces the accumulation of glutamate that is converted into -ketoglutarate instead of being used in glutamate-cysteine exchange and consequently that is why cysteine does not enter the cell and give rise to glutathione

(1991) 260:E101110

Endogenous vasoactive peptides and vascular aging-related diseases

Drug Categories Amino Acids, Peptides, and Proteins Additional Notes Chemically stable in gastric juice (?24 hours) Water-soluble at neutral pH Not approved for human or veterinary use Summary Table Disclaimer For Research Use Only

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