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These include members of the transforming growth factor (TGF-) superfamily, insulin like growth factor 1 (IGF-1), epidermal growth factor (EGF), connective tissue growth factor (CTGF), bone morphogenetic protein-2 (BMP-2), osteogenic protein-1 (OP-1), and growth and differentiation factor-5 and 6 (GDF-5/6) (Kos et al., 2019)

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Peptides can support the process, but they do not replace the fundamentals

Estrogen deficiency is strongly associated with unfavorable changes in fat distribution, particularly increased subcutaneous and visceral fat deposition in the abdomen (59)

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