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N -Acetylcysteine and methionine replenish glutathione to conjugate the toxic metabolite

Molecular regulation of DNA damage and repair in female infertility: a systematic review

Mitochondrial dysfunction also acts as a driver of inflammation as damaged mitochondria release excessive ROS and other byproducts that function as danger signals, activating innate immune pathways but simultaneously inducing low-grade, chronic inflammation (Zampino et al., 2020

With the simple composition of GSH, the biosynthesis is simply done by a single bifunctional enzyme, gshF (bifunctional glutathione synthesis enzyme) (Figure 1)

A1: Glutathione is a naturally occurring tripeptide and major intracellular antioxidant used in laboratory models to investigate redox balance, detoxification, immune function, neurobiology, cartilage and joint health, ocular physiology, and skin-aging mechanisms