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500 mcg per day of vitamin B12 (cobalamin or methylcobalamin)

4 This implies its anti-obesity action does not arise from appetite suppression but rather from a direct metabolic modulation mechanismnamely, the suppression of lipogenesis (fat creation)

2000 in Hormone Research showed that 21-day oral AOD-9604 (500 mcg/kg/day) reduced body weight gain by roughly 50% in obese Zucker rats with no insulin sensitivity penalty

[21] [22] This condition impairs B12 absorption in the terminal ileum and typically requires lifelong parenteral replacement therapy