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Abbreviations FDG: 2-deoxy-2-[ 18 F]fluoro-D-glucose CH 2 -THF: 5,10-methylene tetrahydrofolate 10-CHO-THF: 10-formyl-tetrahydrofolate ATP: adenosine triphosphate GOT: aspartate transaminases ASNS: asparagine synthetase AML: acute myeloblastic leukemia AcCoA: acetyl-coenzyme A Ala: alanine GPT: alanine transaminases aKG: alpha-ketoglutarate BCAT: branched chain aminotransferase Cit: citrate cALL: childhood acute lymphoblastic leukemia P5CS: delta-1-pyrroline-5-carboxylate synthase DHODH: dihydroorotate dehydrogenase ETC: electron transport chain EGF: epidermal growth factor FOCM: folate-mediated one carbon metabolism Fum: fumarate FH: fumarate hydratase Gln: glutamine Glu: glutamate Gly: glycine GS: glutamine synthetase GLS: glutaminase GDH: glutamate dehydrogenase HOTs: human orthotopic tumors HIF: hypoxia inducible factor ICT: isocitrate IDH: isocitrate dehydrogenase Lac: lactate LKB1: liver kinase B1 MS: mass spectrometry mTORC1: mammalian target of rapamycin complex 1 ME: malic enzymes Mal: malate MTHFD: methylenetetrahydrofolate dehydrogenase NADH: nicotinamide adenine dinucleotide, reduced NADPH: nicotinamide adenine dinucleotide phosphate, reduced NNT: nicotinamide nucleotide transhydrogenase NMR: nuclear magnetic resonance OAC: oxaloacetate PET/CT: positron emission tomography integrated with computed tomography PDAC: pancreatic adenocarcinoma Pyr: pyruvate PDH: pyruvate dehydrogenase PC: pyruvate carboxylase PDK: PDH kinase P5C: pyrroline-5-carboxylate PYCR: pyrroline-5-carboxylate reductase POX: proline oxidase ROS: reactive oxygen species Ser: serine SHMT: serine hydroxymethyltransferase SREBP1: sterol regulatory element binding protein 1 Suc: succinate SDH: succinate dehydrogenase TCA: tricarboxylic acid TRAIL: tumor necrosis factor-related apoptosis-inducing ligand References Warburg O

Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein

The functional and structural images were co-registered using boundary-based affine registration from the FsFast software package ( For the surface preprocessing pipeline, the functional images were aligned with the FreeSurfer cortical surface template (fsaverage6, 40,962 vertices per hemisphere)

By inhibiting the expression of HDACs, TSA promotes the transformation of pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages and reduces the infiltration of M2a macrophages