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Upon irradiation with visible light (410 nm), PPIX generates reactive oxygen species (ROS) 24 , which oxidizes Met to Met sulfoxide (MetO), thereby rebalancing noncovalent forces driving a morphological transition from nanofibers (NFs) to spherical nanoparticles (NPs)

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Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV (2019) Blood-Brain Barrier: From Physiology to Disease and Back