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Lin et al., 2009), and MMP-10 (Tsang et al., 2012), which has been observed in different cancer types, such as tongue carcinoma, lung cancer, oral squamous cell carcinoma, and hepatocellular carcinoma

[DOI] [PubMed] [Google Scholar] 41.Tsao C.H., Shiau M.Y., Chuang P.H., Chang Y.H., Hwang J

Ipamorelin has a much shorter half-life of approximately 2 hours, resulting in a rapid rise and fall in growth hormone levels

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In another aspect of the invention, a method of targeted drug delivery of an effective amount of an agent, or a pharmaceutical acceptable carrier comprising an agent, to a target site that is protected by a specific blood-tissue barriers like e.g., the CNS, the blood-brain barrier (BBB), the retina and the testes, is provided wherein: a) the agent or the pharmaceutical acceptable carrier is conjugated to a ligand, that facilitates the specific binding to and internalization by an internalizing GSH uptake receptor of the target site, thereby forming the conjugate as defined above

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