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No clinical trials have been completed in humans to date [8]

In these studies, AOD 9604 was generally safe and well tolerated

Elevated Egr-1 in human atherosclerotic cells transcriptionally represses the transforming growth factor-b type II receptor

Cardiometabolic disease Observational studies demonstrating associations between weight loss in older adults and adverse cardiometabolic outcomes, such as CVD and dementia, fail to discern the intentionality of weight loss [57, 58]

Since the addition of the succinyl group is proposed to have a more profound effect on the spatial conformation and further function of the targeted protein [19], we therefore focused on the biological significance of succinylation modification on GCLC in the following studies