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[15] [16] Biosynthetic pathway [edit] The metabolic pathway to produce ergothioneine starts with the methylation of histidine to produce histidine betaine (hercynine)

Possible explanations include: Placebo effect : Expecting increased energy may influence perceived alertness Correction of deficiency : People with B12 deficiency often experience fatigue and disrupted sleep patterns

While Nrf2 is critical, EpRE binding also involves a partner protein

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2011, doi: 10.1016/j.cell.2011.02.013

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