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In this model, excess ROS plays a role in decreasing the expression of PKC II, as overexpression of GPx1 increases PKC II expression and ERK1/2 activation

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In APP/PS1 transgenic mice, hippocampal iron levels begin to rise at 6 months of age, with an increase of up to 48% observed by month 8

The extensive electrostatic, hydrogen bonding, and hydrophobic interactions on the R-domain explain how mutations distal from phosphorylation sites may nevertheless contribute to dysfunction

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