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EBioMedicine, 24 :16678

Recent research resulted into a clearer picture on the molecular mechanisms underlying ferroptosis that are primed by central roles of the iron metabolism, lipid peroxidation and antioxidants defenses systems

14 members (20.89%) were only expressed in specific cultivars and remained silent in remaining cultivars like Pav_sc0000164.1_g210.1.mk , Pav_sc0001126.1_g250.1.br , Pav_sc0007176.1_g020.1.br , and Pav_sc0000164.1_g200.1.br expressed their expression in only in Bing but remain silent in other cultivars

Hence, when an antioxidant can significantly reduce the level of ROS (most especially mitochondria ROS), mitigate oxidative damage, and improve mitochondrial bioenergetics of FRDA mouse models, it justifies further research in this field to comprehensively assess its therapeutic potentials in FRDA

Pharmaceutical Considerations Page 316 and 317: 285

These systems provide a comprehensive therapeutic model, targeting pathogens, boosting host immunity, and improving regenerative outcomes all at once, in contrast to conventional methods that break down antimicrobial action from tissue repair