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A novel target for next-generation obesity medications is nicotinamide N-methyltransferase (NNMT) 7,8,9,10,11 , an enzyme central to cellular metabolism and energy homeostasis 12

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AOD 9604 works through direct activation of fat cell receptors, bypassing appetite signaling entirely

Running AOD-9604 in parallel with a GHRH analog or a pure 3-AR agonist helps clarify receptor-pathway contributions for any new mechanistic question

The tabular data were processed with the Huttenhower labs linear discriminant analysis (LDA) effect size (LEfSe) tool via the Galaxy module (v1.0) 38
