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[DOI] [PMC free article] [PubMed] [Google Scholar] Badwey J

Animal Studies: Strong Results in Obese Rodent Models The foundational animal work was conducted in obese Zucker rats and ob/ob mice, two standard models for studying obesity

However paper was not the best material to mold a suppository especially considering wettability

"Effect Of Antioxidants On Glucose Metabolism And Plasma Lipids In HIV-Infected Subjects With Lipoatrophy." J Acquir Immune Defic Syndr33.5 (2003): 605-7
However, the requirement for lipophilicity is less strict compared to systemic delivery due to the direct nerve routes available via IN administration

(2018) 102:e4958