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Single-dose OHP increased the sensitivity to cold and mechanical stimulation significantly in WT mice, compared with OCT2 knockout mice, and it was required at the acute OHP-induced peripheral neuropathy onset

In this acetylated form, spermine and spermidine are either oxidatively cleaved into lower polyamines, or alternatively, they can be excreted from the cells into animal body fluids, such as urine or blood [20]

Glutathione: Metabolism and Physiological Functions

& Ji, R.-R

Indeed, because of the complexity associated with the assessment of cellular redox balance, it has been argued that the term oxidative stress defies a simple pro-oxidant versus antioxidant definition and that the description of an oxidant stress is only useful if the molecular details of the imbalance are known (29, 186)