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Lin et al., 2022) This oxidative dysregulation is thought to exacerbate neuroinflammation, mitochondrial dysfunction, and synaptic abnormalities, which may underlie some of the core behavioral and cognitive impairments seen in ASD (Gevezova et al., 2023)

Weight of evidence: Overall evidence is LowModerate in VPA models

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Establishing a link between propionyl-CoA and gene expression would add a new and important axis to our understanding of cardiometabolic disease, ranging from other inborn errors of metabolism 21 (for example, methylmalonic acidaemia) 19 to diabetes 22

Causes While causes of carnitine deficiency is unknown, it is believed some dog breeds show an increased risk of developing the deficiency, including Boxers, Doberman Pinschers, Great Danes, Irish wolfhounds, and other giant breeds