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Description
Intramuscular administration of aripiprazole lauroxil to rats and dogs was associated with injection site tissue reactions at all doses in rats treated up to 6 months at doses of 15, 29, and 103 mg/animal (which are approximately 0.3 to 2 times and 0.5 to 3 times the MRHD of 1064 mg on mg/m2 basis in males and females, respectively) and in dogs treated up to 9 months at doses of 147, 662, and 2058 mg/animal (which are approximately 0.5 to 6 times and 0.6 to 8 times the MRHD in males and females, respectively on mg/m2 basis)
Store at 28C and use within the window stated on the Certificate of Analysis
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With one major caveat
It is a standardized extract of garlic (Allium sativum), which means that it contains a high concentration of the sulfur-containing bioactive compounds allicin and alliin
Nakanishi Y, Iwai M, Hirotani Y, Kato R, Tanino T, Nishimaki-Watanabe H, et al
