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Neurosci Lett (2017) 636:12733.10.1016/j.neulet.2016.10.054 32 JornayvazFRShulmanGI

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Brain GSH levels appear to be decreased in age-related neurodegenerative diseases such as AD, Parkinsons disease (PD), and amyotrophic lateral sclerosis (ALS)

Curcumin is generally considered safe by the FDA, with no major side effects observed at doses of up to 12 g/day [325]

Measurement of Free T4 is of no value in assessing patients on T3

However, the basic nephrotoxin in these herbal remedies has been identified as a diterpene glycoside atractyloside, which in animal studies has been found to affect renal cortical mitochondria and proximal tubular fragments