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LeeDEYooJEKimJKimSKimSLeeHet alNEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Habib E., Linher-Melville K., Lin H.-X., Singh G

Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action As a copper chelator, GHK-Cu modulates over 4,000 human genes, upregulating those involved in tissue remodeling (e.g., collagen I, III) and downregulating pro-inflammatory pathways like NF-B

In a study, the twin with a higher dietary intake of vitamin D, betaine, or methionine exhibited earlier stages of AMD, suggesting that epigenetic modifications may play a crucial role in the pathogenesis of the disease (Seddon et al., 2011)

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