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Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics

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Double staining of blood (CD31 + ) and lymphatic (LYVE1 + ) vessels did not reveal defects in blood vessel growth by loss of Atg5 in LEC (Fig