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4.2.2 Androgens/AR affect the mitochondrial dynamics Mitochondria are dynamic organelles that can be divided into multiple fragmented mitochondria or fused to form an interconnected mitochondrial network to maintain cellular energy homeostasis in response to changes in the cellular environment

However, whether it is harmful or beneficial for subjects with mild cardiovascular diseases or even those without clinical manifestations is still controversial, likely because of the following reasons: (i) similar strains of mice in different studies from different suppliers differ in baseline bacterial gut microbiome, diet (e.g., different choline levels), age of the mice, animal housing conditions, and duration of the experiment

[DOI] [PubMed] [Google Scholar] 611

Kenney: Clearly, the researchers themselves are not saying that TMAO is the real cause of atherosclerosis

2008 Sep 16;105(37):1416914174

These anecdotes underscore the importance of considering personal goals and body chemistry when choosing between these two options