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Several interrelated mechanisms likely underlie this dysregulation, including the hyperglycemic microenvironment, insulin resistance, chronic oxidative stress, and progressive renal structural damage, which collectively impair carnitine homeostasis through multidimensional and cascading pathophysiological mechanisms

16,17 Most slow-wave sleep occurs in the first few sleep cycles

In addition to these QC systems, cells employ mitophagy as an independent surveillance mechanism to eliminate irreversibly damaged or dysfunctional mitochondria through lysosomal degradation 24,25,26,27

doi:10.1161/JAHA.118.010606 67

Notable members include genistein and daidzein, two isoflavonoids garnering substantial scientific interest due to their potential health benefits