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Genetic studies on APAP-induced DILI in humans to date have involved three different approaches: (i) studies in healthy volunteers given APAP at normal doses but showing transient transaminase elevation

[DOI] [PubMed] [Google Scholar] 215.Neely S.M., Gardner D.V., Reynolds N., Green D., Tsao C.H

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doi: 10.1002/pros.21012

These data indicated that CRMP5 was not required for the inhibitory effect of NAC on Notch2 and there might be other molecules which worked together with Itch to mediate the degradation of Notch2 by NAC treatment
