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Description
10.1016/j.coph.2013.08.005 15
Various studies targeting ER stress signaling pathways and components of the UPR have demonstrated that CHAC1 expression is upregulated downstream of the ATF4-dependent signaling pathway (Figure 4)
It has been used extensively in animal studies, human cell models, and increasingly in off-label therapeutic settings, with minimal toxicity or organ stress reported

Key Benefits Supports energy production and metabolism Improves brain function and mood Enhances immune function Reduces stress and fatigue Who Can Benefit
Lancet 373(9669):10971104 Druker BJ et al (2006) Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

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