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Torres et al., 2020

doi: 10.1016/j.jacc.2005.10.065

Some collagen supplements contain biotin, which can cause oiliness and acne in some users, as well as sweets or dairy, which may raise insulin or testosterone levels, leading to increased sebum production

B12 deficiency can come from vegetarian diets, certain medications such as Metformin, and a condition called pernicious anemia wherein the body lacks intrinsic factor, which is necessary for the absorption of B12.

Understanding how they compare to emerging alternatives provides valuable context for anyone making decisions about treatment