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In addition, TMA is formed by the Cys 771 promoting cleavage of choline through a radical exchange with the alpha carbon to form alcohol in the formation of acetaldehyde and TMA ( FIGURE 1 (B) Choline bound to TMA lyase showing key binding interactions with active site amino acid residues that occur upon activation PDB 5AOU

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10.1093/nar/gkf436 15 LiC.ZhaoR.XieM.GuoZ.SunW

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& Carew, T

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