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The Fe atom within active aconitase coordinates with oxygen atoms of citrate and water and acts as a Lewis acid to activate the hydroxyl group of citrate to facilitate the isomerization reaction

This has been confirmed by several studies on traditional antitumors drugs such as olaparib ( via p53/SLC7A11 ( via repressing SLC7A11 ( Targeting the p53/SLC7A11/GPX4 axis has also been found in non-anti-tumor drugs

To investigate whether the OsVIRK1-associated puncta were endocytic vesicles, we co-expressed OsVIRK1-GFP with VPS23A-RFP or ARA7-RFP, two markers of endocytic vesicles, in N

The granuloma is composed of epithelioid histiocytes and multinucleated giant cells, which will contain M

Such regulatory understanding has, in turn, had important ramifications for drug design and disease etiology