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Moreover, Dox-induced ATF6 knockdown in Colo201 tumor xenografts resulted in an over 70% reduction in tumor volume

In the group of retinas observed 2 wk after AAV2-CAG-hEDN1 injection, there was no significant change in the distribution or quantity of RGCs compared with the group of retinas injected with AAV2-CAG-stuffer as a control vector (Fig S2AD)

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First, nanocarriers directly deliver ferroptosis modulators to molecular targets, depleting GSH via cystine disruption, inhibiting GPX4, or elevating labile iron pools to amplify lipid peroxidation