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Defective autophagy of old mitochondria (mitophagy) can also be a major source of ROS [87]

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showed that mitophagy receptor protein FUNDC1 located at the mitochondrial outer membrane that is associated with cytoplasmic chaperone protein HSC70, leading to the recruitment of damaged or misfolded cytosolic proteins to mitochondria, and then shuttle to the mitochondrial matrix through the TOMTIM complex, culminating with the degradation by matrix-localized mitochondrial protease LONP1

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