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Zinc Depletion Long-term, high-dose use of glutathione may lead to lower levels of zinc

The distribution coefficient is the ratio of the sum of the concentrations of all species of the compound in octanol to the sum of the concentrations of all species of the compound in water

doi: 10.1007/s11064-015-1567-4 450 KimHKChoiBRBakYOZhaoCLeeSWJeonJHet al

288 Furthermore, dysregulation of Wnt3a, -catenin, and HIF-1, as well as antioxidant enzyme activities (Mn-SOD, Cu/Zn-SOD, glutathione and CAT), synergistically promotes oxidative stress by inhibiting the Wnt/-catenin and HIF-1 signaling pathways in the liver during I/R injury

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