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Shared epigenetic resistance mechanisms/targets of sorafenib and lenvatinib The epigenetic mechanisms underlying sorafenib/lenvatinib resistance encompass shared regulatory processes, including DNA/RNA methylation, histone modifications, and non-coding RNA regulation, and shared resistance outcomes involving dysregulated programmed cell death, metabolic reprogramming, enhanced cancer stem cell properties, and uncontrolled proliferative signaling pathways

Eur J Pharmacol 131:105109, 1986 Sikiric P, Rotkvic I, Mise S, Krizanac S, Suchanek E, Petek M, Gjuris V, Tucan-Foretic M, Udovicic I, Anic T, Balen I: The influence of dopamine agonists and antagonists on gastric lesions in mice

Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte D (1987) Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance

Environ Chem Lett 17:11951208 Gaur JP, Rai LC (2001) Heavy metal tolerance in algae

24 h post-LPS challenge) dose-dependently enhances autophagy in LPS-challenged A549 cells, as shown by increased LC3-II and decreased p62 protein levels [6]