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KRAS mutant NSCLC is highly susceptible to resistance to the MEK inhibitor trametinib

Geriatric patients may be more susceptible to these effects

Stress Biol 5(1):5 Johnsirani P, Wani AA, Bharatam PV, Nanjappan S (2020) LCESIQTOFMS analysis utilizing gas-phase fragmentation reactions subjected to ESIISCID and ESICIDMS/MS conditions to study the degradation behaviour of sorafenib tosylate: NMR and in vitro cytotoxicity and apoptosis detection studies of hydrolytic degradation products

Pettegrew et al

We measured the global acyl-CoA content in the Gly and CKO groups and showed that PRMT1 knockdown in TECs increased acyl-CoA content, indicating increased fatty acid metabolism (Fig