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In accordance to the activation of HIF-1 (Figure 5A), roxadustat significantly increased the PFKFB3 expression on mRNA and protein level in a dose-dependent manner in both neurons and astrocytes (Figure 8B)

[3] Epitalon reduced the number of spontaneous tumors and the number of metastases in mice that did develop spontaneous tumors in an experiment on one-year-old female mice of the C3H/He inbred strain, and is speculated to have oncostatic and anti-metastatic properties

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Tpit determines alternate fates during pituitary cell differentiation